Description
Kisspeptin-10
Metastin (45–54) Amide
A decapeptide agonist of the KISS1R (GPR54) receptor — the most upstream known regulator of the reproductive axis, and the master signal that initiates GnRH release and governs the onset of puberty.
The master switch of the reproductive axis — one tier above every hormone it commands.
| Kisspeptin-10 is the shortest bioactive fragment of the kisspeptin family, corresponding to the C-terminal residues 45–54 of the KISS1 gene product (metastin). As a high-affinity agonist of the KISS1R / GPR54 receptor, it sits at the very top of the hypothalamic–pituitary–gonadal (HPG) hierarchy — the signal that tells GnRH neurons when to fire.
At Guardian Labs, Kisspeptin-10 is supplied as a research-grade lyophilized powder, HPLC-verified above ninety-nine percent purity and lot-verified, so your neuroendocrine, reproductive, and receptor-signaling data remain accurate and reproducible. |
Loss-of-function mutations in the KISS1R receptor prevent the onset of puberty entirely — a discovery that placed kisspeptin at the center of modern reproductive neuroendocrinology.
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Four sequential steps — from receptor binding to gonadal output.
i
KISS1R ActivationBinds the GPR54 (KISS1R) receptor with nanomolar affinity, triggering Gq-coupled calcium mobilization in target neurons — the initiating event of the cascade. |
ii
GnRH ReleaseActivates hypothalamic GnRH neurons to secrete gonadotropin-releasing hormone in a pulsatile pattern — the rhythm that drives the entire reproductive axis. |
iii
LH & FSH CascadeGnRH signals the anterior pituitary to release luteinizing hormone and follicle-stimulating hormone, the gonadotropins that command downstream steroidogenesis. |
iv
Central & Peripheral RolesBeyond the HPG axis, KISS1R signaling is studied in emotional and behavioral processing, bone (osteoblast differentiation), and metabolic regulation. |
On Upstream Regulation
Unlike peptides that act at the pituitary or gonad, kisspeptin operates one level higher — at the hypothalamic neurons that gate GnRH itself. This upstream position, working through the body’s own pulsatile machinery rather than overriding it, is precisely why kisspeptin has become a leading subject in fertility and reproductive-axis research.
Primary subjects of investigation — strictly laboratory use.
A.01
Reproductive EndocrinologyStudies of HPG-axis regulation, LH/FSH pulse dynamics, and the neuroendocrine control of gonadotropin secretion. |
A.02
Fertility & Oocyte ModelsResearch into kisspeptin as an oocyte-maturation trigger and its potential to reduce ovarian hyperstimulation in assisted-reproduction models. |
A.03
Puberty & DevelopmentInvestigating KISS1R receptor mutations, the timing of pubertal onset, and developmental sex-hormone signaling. |
A.04
Neuroendocrine & BehaviorExamining kisspeptin’s central role in emotional and behavioral processing, and in models of hypothalamic amenorrhea. |
Peer-reviewed literature supporting the research potential of this neuropeptide.
| i. |
Potent Stimulation of Luteinizing HormoneA clinical investigation demonstrating that kisspeptin-10 administration robustly stimulates luteinizing hormone secretion and increases LH pulse frequency — establishing its role as a direct upstream driver of the reproductive axis. |
View on PubMed → |
| ii. |
Fertility & Reduced Hyperstimulation RiskResearch examining kisspeptin as a trigger for oocyte maturation, reporting suppression of the signaling associated with ovarian hyperstimulation syndrome — an area of active interest in assisted-reproduction models. |
View on PubMed → |
| iii. |
Central Emotional & Behavioral ProcessingNeuroimaging studies indicating that kisspeptin modulates brain activity in regions governing emotional and behavioral response — extending its research relevance beyond peripheral endocrinology. |
View on PubMed → |
| iv. |
Osteoblast Differentiation via GPR54An exploratory analysis reporting that kisspeptin-10 promotes osteoblast differentiation through GPR54-mediated BMP2 signaling — one of several peripheral pathways now under investigation. |
View on PubMed → |
Certificate of analysis available upon request.
| Chemical Name | Kisspeptin-10 (human) · Metastin (45–54) Amide |
| Sequence | H-Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH₂ |
| Molecular Formula | C₆₃H₈₃N₁₇O₁₄ |
| Molecular Weight | 1302.45 g/mol |
| CAS Number | 374675-21-5 |
| Receptor Target | KISS1R / GPR54 |
| Format | Lyophilized Powder (Freeze-dried) |
| Vial Size | 10 mg |
| Purity | > 99% (HPLC Verified) |
| Storage | Store at −20°C · Protect from light |
| Reconstitution | Bacteriostatic Water |
All products listed are intended exclusively for laboratory research and development purposes. They are not intended for human consumption, diagnostic, or therapeutic use. Customers must be at least 21 years of age to purchase.
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