Description
5-Amino-1MQ 50mg
5-Amino-1MQ 50mg is a selective, membrane-permeable NNMT inhibitor used in research on the NAD+ salvage pathway and cellular metabolism. Each lot is HPLC-verified above 99% purity, with its Certificate of Analysis in our COA library.
What is 5-Amino-1MQ?
5-Amino-1MQ is a synthetic small molecule derived from methylquinolinium. Rather than mimicking a hormone, it selectively inhibits nicotinamide N-methyltransferase (NNMT), the enzyme that converts nicotinamide into 1-methylnicotinamide. Guardian Labs supplies 5-Amino-1MQ 50mg as a research-grade compound, HPLC-verified above 99% purity.
How 5-Amino-1MQ works in research models
When NNMT is blocked, nicotinamide stays available to the NAD+ salvage pathway instead of being methylated. Studies use 5-Amino-1MQ to examine:
i
NAD+ levelsIntracellular NAD+ concentrations after NNMT inhibition |
ii
SIRT1 signalingNAD+-dependent sirtuin activity |
iii
Adipose and muscle modelsWhite adipose tissue and muscle satellite cell behavior in diet-induced obesity models |
Specifications
| Compound | 5-Amino-1-methylquinolinium (5-Amino-1MQ) |
| Amount | 50mg per vial |
| Purity | >99% (HPLC) |
| Testing | Lot COA in the Guardian Labs COA library |
Quality and testing
Every lot is third-party tested, and its Certificate of Analysis is published in our COA library, searchable by product and lot number.
Frequently asked questions
What is 5-Amino-1MQ used for in research?
It’s used to study NNMT inhibition and its downstream effects on the NAD+ salvage pathway and cellular metabolism.
Is 5-Amino-1MQ a peptide?
No. It’s a small-molecule methylquinolinium derivative, not a peptide.
Is there a COA?
Yes. The current lot’s COA is in our COA library.
Research Use OnlyFor laboratory research use only. Not for human consumption. Must be 21+ to purchase. Not intended to diagnose, treat, cure or prevent any disease.
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