Description

5-Amino-1MQ (NNMT Inhibitor)

5-Amino-1MQ is a synthetic small molecule derivative of methylquinolinium. Unlike traditional peptides that mimic hormones, 5-Amino-1MQ functions as a selective inhibitor of the enzyme Nicotinamide N-methyltransferase (NNMT). By blocking this enzyme, it prevents the metabolic “waste” of Nicotinamide, forcing the body to recycle it into NAD+ (Nicotinamide Adenine Dinucleotide).

At Guardian Labs, we provide 5-Amino-1MQ in its purest research-grade form. Each batch is HPLC-verified to ensure >99% purity, offering researchers a precise tool for investigating cellular metabolism, mitochondrial efficiency, and muscle satellite cell function.

What is 5-Amino-1MQ?

5-Amino-1MQ was developed to target the “salvage pathway” of cellular energy. In conditions of obesity and aging, the enzyme NNMT becomes overactive, converting useful Nicotinamide into 1-methylnicotinamide (1-MNA), a metabolic dead-end.

By inhibiting NNMT, 5-Amino-1MQ drives a significant increase in intracellular NAD+ levels. Elevated NAD+ is a critical cofactor for sirtuins (SIRT1), often referred to as “longevity genes,” which regulate metabolic rate and DNA repair. This unique mechanism has made 5-Amino-1MQ a primary candidate for research into reversing metabolic dysfunction without the use of central nervous system stimulants.

Mechanism of Action

The biological impact of 5-Amino-1MQ is driven by the “NNMT Blockade”:

• NAD+ Restoration: By preventing NNMT from methylating Nicotinamide, the cell is forced to funnel that substrate into the NAD+ salvage pathway. Research shows this can increase cellular NAD+ concentrations significantly.

• SIRT1 Activation: The subsequent rise in NAD+ activates SIRT1 enzymes, which are responsible for increasing mitochondrial biogenesis and fat oxidation.

• Adipocyte Shrinkage: Unlike agents that simply suppress appetite, 5-Amino-1MQ appears to correct the metabolic profile of white adipose tissue (fat cells), causing them to shrink in size and behave more like metabolically active brown fat.

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Potential Research Applications

5-Amino-1MQ is distinct in its ability to target both adipose tissue and skeletal muscle simultaneously. Key areas of investigation include:

• Muscle Satellite Cells: Recent studies suggest that NNMT inhibition can rejuvenate “aged” muscle stem cells (satellite cells), promoting regeneration and increasing contractile strength in elderly models.

• Obesity & Lipogenesis: Investigating the reduction of white adipose tissue mass and the reversal of diet-induced obesity independent of food intake reduction.

• Metabolic Syndrome: Researching the compound’s ability to lower cholesterol and improve glucose tolerance by correcting the underlying energy deficit in cells.

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Scientific References

To validate the efficacy of NNMT inhibition, we reference the following pivotal studies.

1. Reversal of Diet-Induced Obesity

Summary: This study identified 5-Amino-1MQ as a potent, membrane-permeable NNMT inhibitor. Treatment in diet-induced obese mice resulted in a 30% reduction in body mass and a significant decrease in white adipose tissue size, all without altering food intake. The study concluded that NNMT inhibition effectively increases cellular energy expenditure.

• View the study on PubMed

2. Muscle Satellite Cell Rejuvenation

Summary: A 2024 study published in Scientific Reports demonstrated that treatment with 5-Amino-1MQ significantly improved grip strength in aged mice. The mechanism was linked to the restoration of NAD+ levels in muscle tissue, which enhanced the function of senescent muscle satellite cells, suggesting a potential therapy for sarcopenia (age-related muscle loss).

• View the study on PubMed

3. Oral Bioavailability & Pharmacokinetics

Summary: This pharmacological analysis validated a method for detecting 5-Amino-1MQ in plasma. It confirmed that the small molecule has substantial bioavailability when administered orally in rat models, distinguishing it from many peptides that require injection.

• View the study on PubMed

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Product Specifications

• Chemical Name: 5-amino-1-methylquinolinium

• Formula: C10H11IN2

• Format: Powder (Stable Salt Form)

• Purity: >99% (HPLC Verified)

• Solubility: Soluble in water and DMSO.

• Storage: Store at room temperature (short term) or -20°C (long term). Keep away from light.

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  Disclaimer: All products listed on this site are for laboratory research and development purposes only. They are not intended for human consumption, diagnostic, or therapeutic use. Customers must be at least 18 years old to purchase.