Description

CJC-1295 w/o DAC (Modified GRF 1-29)

CJC-1295 w/o DAC, scientifically known as Modified GRF 1-29, is a synthetic analogue of the endogenous Growth Hormone Releasing Hormone (GHRH). This peptide is a staple in research settings aimed at understanding the pulsatile release of growth hormone without the extended half-life associated with the DAC (Drug Affinity Complex) variation.

At Guardian Labs, we provide premium CJC-1295 w/o DAC that undergoes rigorous third-party testing. We guarantee >99% purity to ensure the accuracy and reliability of your laboratory research.

What is CJC-1295 w/o DAC?

CJC-1295 w/o DAC is a tetrasubstituted peptide comprised of 29 amino acids. It represents a “modified” version of the shortest functional fragment of GHRH. The modification involves the substitution of four specific amino acids, which grants the peptide significant resistance to enzymatic cleavage.

Because it lacks the Drug Affinity Complex (DAC), this peptide possesses a shorter half-life of approximately 30 minutes. This characteristic allows researchers to mimic the body’s natural, pulsatile secretion of growth hormone, making it an ideal subject for studies investigating natural circadian rhythms.

Mechanism of Action

The primary function of CJC-1295 w/o DAC is to act as a GHRH agonist. It binds selectively to the GHRH receptor on the anterior pituitary gland. Research indicates that this binding stimulates the release of growth hormone (GH) in distinct pulses rather than a continuous bleed.

Potential Research Applications

While this product is strictly for in-vitro and laboratory use, animal and clinical studies have identified several key areas of interest:

• Muscle Protein Synthesis: Studies suggest GHRH analogues may influence cellular repair and hypertrophy in muscle tissue.

• Lipolysis (Fat Loss): Ongoing research is investigating how pulsatile GH release affects the breakdown of adipose tissue.

• Injury Recovery: There is a potential link between elevated growth factors (IGF-1) and reduced recovery time in connective tissue injuries.

The Difference: With vs. Without DAC

A common point of confusion in peptide research is the distinction between the two forms of this molecule.

1. CJC-1295 w/o DAC (Mod GRF 1-29): Rapid acting with a short half-life. It is used to replicate natural GH spikes. It generally requires more frequent administration in test subjects.

2. CJC-1295 with DAC: Contains a Drug Affinity Complex that binds to serum albumin, extending the half-life to several days. This causes a continuous “bleed” of GH rather than natural pulses.

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Scientific References

To validate the mechanism and stability of this peptide, we reference the following peer-reviewed studies. These trials highlight the efficacy of the modified GHRH 1-29 sequence in laboratory settings.

1. Restoration of GH Levels

Summary: This pivotal study investigated the administration of GHRH 1-29 in older male subjects. The data confirmed that this specific amino acid sequence could reverse age-related declines in growth hormone (somatopause), effectively restoring GH and IGF-1 to levels comparable to those found in healthy young adults.

• View the study on PubMed

2. Enhanced Peptide Stability (D-Ala2 Modification)

Summary: This research explains the critical “modification” in Mod GRF 1-29. By substituting the second amino acid with D-Alanine, researchers observed a significant resistance to enzymatic breakdown. This modification is what allows CJC-1295 w/o DAC to possess a vastly improved metabolic clearance rate compared to native GHRH.

• View the study on PubMed

3. Benefits of Pulsatile Secretion

Summary: Unlike continuous delivery methods (which can desensitize receptors), this study highlights the biological importance of pulsatile GH secretion. The findings suggest that mimicking the body’s natural “spikes”—mechanistically achievable with CJC-1295 w/o DAC—is superior for regulating bone formation markers and specific metabolic enzymes.

• View the study on PubMed

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Product Specifications

• Sequence: Tyr-D-Ala-Asp-Ala-Ile-Phe-Thr-Gln-Sy-Tyr-Arg-Lys-Val-Leu-Ala-Gln-Leu-Sark-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Leu-Ser-Arg-NH2

• Format: Lyophilized Powder (Freeze-dried)

• Vial Size: 2mg / 5mg

• Purity: >99% (HPLC Verified)

• Storage: Store at -20°C. Reconstitute with Bacteriostatic Water.

Disclaimer: All products listed on this site are for laboratory research and development purposes only. They are not intended for human consumption, diagnostic, or therapeutic use. Customers must be at least 18 years old to purchase.