Glutathione 1500mg
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Glutathione (1500mg)

Original price was: $70.00.Current price is: $56.00.

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Master Intracellular Antioxidant

A reduced Glu–Cys–Gly tripeptide — the cell’s most abundant antioxidant and the anchor of redox balance.

Glutathione (GSH) neutralizes reactive oxygen species, powers glutathione-peroxidase and phase II detoxification, and regenerates vitamins C and E — cycling continuously between its reduced and oxidized forms. The GSH:GSSG ratio is a primary readout of cellular health. Research-grade, HPLC verified, and lot-verified.

> 99% Purity307.32 Da1500 mg VialHPLC Verified

Research Use Only Not for human consumption. For laboratory research and development only. Must be 21+ to purchase.

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SKU: GL-Glutathione-1500mg Categories: , Brand:

Third-Party Testing

Tested lot
YPB.259
Laboratory
Analytical Formulations, Inc.
Client on COA
PureMD Labs (manufacturer: YPB Labs)
Purity
98.5%
Test date
28 December 2025 (Performing Analyst date)

View full testing record →  |  Original COA (PDF)

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    Description

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    ResearchTripeptide AntioxidantLot Verified

    Glutathione (GSH)
    γ-L-Glutamyl-L-Cysteinyl-Glycine

    The cell’s master antioxidant — a reduced tripeptide of glutamate, cysteine, and glycine that anchors redox balance, drives detoxification, and regenerates the wider antioxidant network.

    > 99% PurityHPLC VerifiedLyophilized Powder1500 mg Vial

    > 99%HPLC Purity
    307.32MW (Da)
    1500 mgPer Vial
    −20°CStorage

    § 01 — The Antioxidant

    The most abundant intracellular antioxidant — present in every cell, central to redox life.

    Glutathione is a tripeptide built from glutamate, cysteine, and glycine — with a reactive thiol (–SH) group on its cysteine residue that gives the molecule its defining chemistry. It is the most abundant antioxidant inside the cell, cycling continuously between its reduced (GSH) and oxidized (GSSG) states as it neutralizes reactive species and maintains cellular redox balance.

    At Guardian Labs, glutathione is supplied in its reduced form as a research-grade lyophilized powder — HPLC-verified above ninety-nine percent purity and lot-verified — so your oxidative-stress, detoxification, and redox-signaling data remain accurate and reproducible.
    Glutathione is not consumed once and discarded — it is continuously recycled between reduced and oxidized forms, making the GSH:GSSG ratio a primary readout of cellular redox status.

    § 02 — Biochemical Roles

    Four intersecting functions — where glutathione governs cellular defense.

    i

    ROS Scavenging

    The cysteine thiol directly neutralizes free radicals and reactive oxygen species, donating electrons to quench oxidative damage before it propagates.

    		 ii

    Peroxidase Cofactor

    Serves as the electron donor for glutathione peroxidase enzymes, reducing hydrogen and lipid peroxides to water — then recycling from GSSG back to GSH.

    		 iii

    Phase II Detox

    Conjugates xenobiotics, heavy metals, and reactive electrophiles via glutathione-S-transferases, tagging them for safe elimination from the cell.

    		 iv

    Antioxidant Recycling

    Regenerates oxidized vitamins C and E back to their active forms, extending and reinforcing the cell’s broader antioxidant network.
    ✦

    On the Redox Ratio

    The balance between reduced (GSH) and oxidized (GSSG) glutathione is one of the most-studied indicators of cellular health. A high GSH:GSSG ratio signals a well-defended, reducing intracellular environment; its collapse is a hallmark of oxidative stress across aging, metabolic, and neurodegenerative research models — making glutathione a central molecule in redox biology.

    § 03 — Research Applications

    Primary subjects of investigation — strictly laboratory use.

    A.01

    Oxidative Stress

    Studies of redox homeostasis, reactive-oxygen-species handling, and the GSH:GSSG ratio as a marker of cellular defense.

    		 A.02

    Detoxification

    Research into phase II conjugation, xenobiotic and heavy-metal clearance, and hepatic detoxification pathways.

    		 A.03

    Cellular Protection

    Investigating mitochondrial protection, apoptosis regulation, and glutathione depletion in aging and neurodegenerative models.

    		 A.04

    Dermatological

    Examining glutathione’s role in melanogenesis and tyrosinase modulation — a well-studied line in skin and pigmentation research.

    § 04 — Scientific References

    Peer-reviewed literature supporting the research potential of this tripeptide.

    i.

    Glutathione & Redox Homeostasis

    A foundational review characterizing glutathione as the principal intracellular redox buffer, detailing the GSH:GSSG cycle and its role as the central regulator of cellular oxidative balance.

    		 View on PubMed →
    ii.

    Detoxification & Conjugation

    Research characterizing the glutathione-S-transferase family and glutathione conjugation as the primary phase II route for clearing electrophiles, xenobiotics, and reactive metabolites.

    		 View on PubMed →
    iii.

    Glutathione Depletion & Aging

    Studies reporting that intracellular glutathione declines with age and metabolic stress, with measurable consequences for mitochondrial function and susceptibility to oxidative injury.

    		 View on PubMed →
    iv.

    Glutathione & Melanogenesis

    Investigations into glutathione’s modulation of tyrosinase activity and the eumelanin–pheomelanin balance — the mechanistic basis for its role in pigmentation research.

    		 View on PubMed →

    § 05 — Product Specifications

    Certificate of analysis available upon request.

    Chemical Name L-Glutathione (Reduced) · γ-L-Glutamyl-L-Cysteinyl-Glycine
    Composition Tripeptide (Glutamate · Cysteine · Glycine)
    Molecular Formula C₁₀H₁₇N₃O₆S
    Molecular Weight 307.32 g/mol
    CAS Number 70-18-8
    Format Lyophilized Powder (Freeze-dried)
    Vial Size 1500 mg
    Purity > 99% (HPLC Verified)
    Storage Store at −20°C · Protect from light & air
    Reconstitution Bacteriostatic Water

    Research Use OnlyAll products listed are intended exclusively for laboratory research and development purposes. They are not intended for human consumption, diagnostic, or therapeutic use. Customers must be at least 21 years of age to purchase.

    Additional information

    Weight 0.0625 lbs

    Independent Laboratory Testing

    View available Certificates of Analysis for this research product.

    Lot GL-GTT1500MG-04-202610-001 Lot page
    Browse all Certificates of Analysis

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