Description

KLOW Blend (Dermal & Tissue Research)

The KLOW Blend is a comprehensive “Quad-Action” formulation designed for advanced dermatological and soft tissue research. It combines the regenerative power of BPC-157 and TB-500 with the skin-remodeling properties of GHK-Cu (Copper Peptide) and the potent anti-inflammatory effects of KPV (Alpha-MSH fragment).

At Guardian Labs, we have engineered this blend to provide researchers with a synergistic tool for investigating the complex pathways of wound healing, collagen synthesis, and microbiome regulation in tissue models. Every vial is HPLC-verified to ensure >99% purity.

What is the KLOW Blend?

This unique stack addresses tissue health from four distinct biological angles:

1. GHK-Cu (Copper Tripeptide-1): A naturally occurring copper complex known in research to stimulate the production of collagen and elastin, while downregulating oxidative stress markers.

2. KPV (Lysine-Proline-Valine): A C-terminal fragment of alpha-melanocyte-stimulating hormone (alpha-MSH). It is widely studied for its potent antimicrobial and anti-inflammatory properties, particularly in psoriatic or acne-prone tissue models.

3. BPC-157: Promotes angiogenesis (new blood vessel formation), ensuring adequate nutrient delivery to repairing tissues.

4. TB-500: Facilitates cell migration and actin polymerization, accelerating the closure of wounds and structural repair.

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Mechanism of Action

The KLOW Blend operates via a “Repair and Remodel” pathway:

• Collagen & Elastin Synthesis: GHK-Cu acts as a feedback signal for tissue remodeling, prompting fibroblasts to generate new collagen and glycosaminoglycans (GAGs), which are essential for skin firmness and elasticity.

• Inflammation Modulation: KPV exerts its effects by inhibiting the NF-kappaB pathway, a key regulator of inflammation. This makes it highly effective in reducing redness and irritation in experimental models.

• Accelerated Regeneration: While GHK-Cu and KPV modulate the tissue environment, BPC-157 and TB-500 drive the physical repair process by enhancing vascular flow and cellular motility.

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Potential Research Applications

This blend is frequently utilized in studies focusing on aesthetics, dermatology, and regenerative medicine. Key areas of interest include:

• Dermal Rejuvenation: Evaluating the blend’s ability to reverse photoaging, reduce fine lines, and improve skin texture in ex-vivo skin models.

• Wound Healing & Scarring: Investigating how the combination of actin sequestration (TB-500) and collagen regulation (GHK-Cu) affects scar tissue formation.

• Scalp & Hair Follicle Health: Researching the effects of GHK-Cu and TB-500 on hair follicle size and the anagen (growth) phase of the hair cycle.

• Antimicrobial Activity: Studies utilizing KPV to combat Cutibacterium acnes and Staphylococcus aureus on skin surfaces.

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Scientific References

To validate the multi-faceted potential of these peptides, we reference the following peer-reviewed studies.

1. GHK-Cu and Skin Remodeling

Summary: This comprehensive review details the regenerative actions of GHK-Cu. It highlights the peptide’s ability to reset the gene expression of human fibroblasts to a healthier state, stimulating collagen and elastin production while simultaneously repairing DNA damage.

• View the study on PubMed

2. Anti-Inflammatory Effects of KPV

Summary: Research into alpha-MSH fragments identified KPV as a potent anti-inflammatory agent. The study demonstrated that KPV could effectively inhibit NF-kappaB activation and reduce inflammatory cytokines in corneal and dermal cells, suggesting broad therapeutic potential for inflammatory skin conditions.

• View the study on PubMed

3. Synergistic Wound Healing

Summary: While focusing on individual components, this literature supports the hypothesis that combining angiogenic agents (like BPC-157) with cell migration factors (TB-500) significantly accelerates the rate of wound closure and improves the tensile strength of repaired tissue.

• View the study on PubMed

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Product Specifications

• Components: GHK-Cu, KPV, BPC-157, TB-500

• Format: Lyophilized Powder (Freeze-dried)

• Appearance: Distinctive Blue Tint (due to Copper content in GHK-Cu)

• Purity: >99% (HPLC Verified)

• Storage: Store at -20°C. Reconstitute with Bacteriostatic Water.

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  Disclaimer: All products listed on this site are for laboratory research and development purposes only. They are not intended for human consumption, diagnostic, or therapeutic use. Customers must be at least 18 years old to purchase.