Description
What is KPV?
KPV is a three-amino-acid peptide: lysine, proline and valine. It corresponds to residues 11–13 at the C-terminal end of α-melanocyte-stimulating hormone (α-MSH), the region associated with α-MSH’s anti-inflammatory activity in research models. Its small size has made it a subject of interest for studying that activity in isolation.
Compound details
| Sequence | Lys-Pro-Val (KPV) | Molecular formula | C16H30N4O4 | Molecular weight | ≈ 342.4 g/mol | Origin | C-terminal fragment of α-MSH (residues 11–13) | Amount | 10 mg per vial | Form | Lyophilized powder |
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Research context
- Inflammatory signaling: studied for inhibition of NF-κB activation and pro-inflammatory cytokine production in cell models.
- Intestinal epithelium: investigated in intestinal epithelial cell and experimental colitis models, including uptake through the PepT1 peptide transporter.
- Skin and barrier research: examined in keratinocyte and other epithelial models.
- Antimicrobial activity: studied for activity against microorganisms in laboratory models.
Third-party testing
Published COAs and batch testing records are listed on the Certificates of Analysis page.
Storage
Keep refrigerated or frozen, protected from light. For long-term storage of the lyophilized powder, −20 °C is recommended.
See our guide to storing and handling research peptides.
For laboratory research use only. Not for human or veterinary use. Not intended to diagnose, treat, cure or prevent any disease. Statements have not been evaluated by the FDA.
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