Description

MOTS-c (Mitochondrial Derived Peptide)

MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA-c) is a peptide of 16 amino acids that has revolutionized the understanding of metabolic signaling. Unlike most peptides which are encoded by nuclear DNA, MOTS-c is encoded within the DNA of the mitochondria itself. It is widely classified in research as an “exercise mimetic” due to its ability to simulate the cellular benefits of physical training.

At Guardian Labs, we provide MOTS-c in its purest synthesized form. Every vial is subject to rigorous HPLC testing to ensure >99% purity, giving researchers a reliable tool to investigate mitochondrial function, aging, and metabolic flexibility.

What is MOTS-c?

MOTS-c is a key regulator of metabolic homeostasis. It was discovered to be a signaling molecule that communicates between the mitochondria and the nucleus in response to metabolic stress.

In research settings, MOTS-c has gained attention for its ability to prevent diet-induced obesity and insulin resistance in mouse models, even without a change in calorie intake. It functions largely by targeting skeletal muscle, enhancing glucose uptake, and improving fatty acid oxidation.

Mechanism of Action: The “Exercise Mimetic”

The primary mechanism of MOTS-c involves the folate-methionine cycle and the activation of AMPK (AMP-activated protein kinase).

• AMPK Activation: Similar to the drug AICAR or intense physical exercise, MOTS-c activates AMPK in skeletal muscle. This enzyme acts as a “master switch” for metabolism, signaling the body to burn glucose and fatty acids for energy.

• AICAR Ribonucleotide: MOTS-c increases cellular levels of AICAR (5-aminoimidazole-4-carboxamide ribonucleotide), which is a direct activator of AMPK.

• Nuclear Translocation: Uniquely, MOTS-c can translocate to the cellular nucleus to regulate gene expression related to antioxidant responses and metabolic adaptation.

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Potential Research Applications

MOTS-c is currently being investigated for its potential to combat metabolic diseases and age-related decline. Key areas of study include:

• Metabolic Flexibility: Researching how the peptide prevents weight gain and insulin resistance under high-fat diet conditions.

• Physical Performance: Studies have shown that MOTS-c treatment in older mice significantly improved physical capacity and running time, suggesting a reversal of age-dependent physical decline.

• Bone Health: emerging evidence suggests MOTS-c may promote osteoblast (bone-forming cell) differentiation.

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Scientific References

To validate the unique mitochondrial origin and metabolic effects of this peptide, we reference the following pivotal studies.

1. The Discovery of MOTS-c & Metabolism

Summary: This seminal paper identified MOTS-c as a mitochondrial-derived peptide. The study demonstrated that MOTS-c targets skeletal muscle to enhance glucose metabolism. Mice treated with the peptide were protected against diet-induced obesity and insulin resistance, highlighting its role as a regulator of metabolic homeostasis.

• View the study on PubMed

2. Reversal of Age-Related Physical Decline

Summary: This study explored the effects of MOTS-c on aging. The researchers found that MOTS-c levels naturally decline with age. Systemic treatment in older mice notably enhanced physical performance (running capacity) and grip strength, suggesting it can rejuvenate skeletal muscle function.

• View the study on PubMed

3. Improvement of Insulin Sensitivity

Summary: Research focusing on the peptide’s mechanism confirmed that it acts through the folate cycle to increase AICAR levels, subsequently activating AMPK. This pathway is critical for improving insulin sensitivity and clearing glucose from the bloodstream.

• View the study on PubMed

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Product Specifications

• Sequence: Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg

• Format: Lyophilized Powder (Freeze-dried)

• Vial Size: 5mg / 10mg

• Purity: >99% (HPLC Verified)

• Storage: Store at -20°C. Reconstitute with Bacteriostatic Water.

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  Disclaimer: All products listed on this site are for laboratory research and development purposes only. They are not intended for human consumption, diagnostic, or therapeutic use. Customers must be at least 18 years old to purchase.