Description
MOTS-c 40mg
MOTS-c 40mg is a 16-amino-acid peptide encoded by the mitochondrial genome, studied for AMPK activation and metabolic signaling between the mitochondria and the nucleus. HPLC-verified above 99% purity, with a lot COA in our library.
What is MOTS-c?
MOTS-c (mitochondrial open reading frame of the 12S rRNA type-c) is a 16-amino-acid peptide encoded in mitochondrial DNA rather than nuclear DNA. That places it in a small, growing class of mitochondrial-derived peptides that appear to act as signals from the mitochondria to the rest of the cell. Guardian Labs supplies MOTS-c 40mg as a lyophilized research peptide, HPLC-verified above 99% purity.
Mechanisms studied in MOTS-c research
i
AMPK activationA central regulator of cellular energy balance |
ii
Metabolic homeostasisGlucose and fatty-acid handling in research models |
iii
Retrograde signalingMovement to the nucleus under metabolic stress, influencing gene expression |
iv
Exercise physiologyStudied in exercise-adjacent metabolic pathways |
Specifications
| Length | 16 amino acids |
| Molecular weight | 2174.60 Da |
| Purity | >99% (HPLC) |
| Amount | 40mg per vial, lyophilized |
Quality and testing
The current lot’s Certificate of Analysis is in our COA library.
Frequently asked questions
What does MOTS-c stand for?
Mitochondrial open reading frame of the 12S rRNA type-c.
Why is MOTS-c unusual?
It’s encoded by mitochondrial DNA, not nuclear DNA.
What is MOTS-c studied for?
AMPK activation, metabolic homeostasis and mitochondria-to-nucleus signaling in research models.
Research Use OnlyFor laboratory research use only. Not for human consumption. Must be 21+ to purchase. Not intended to diagnose, treat, cure or prevent any disease.
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