Description

Pinealon (Pineal Gland Bioregulator)

Pinealon is a synthetic tripeptide (Glu-Asp-Arg) belonging to the class of compounds known as “Bioregulators.” Originally identified by the Khavinson Institute, Pinealon is designed to interact directly with the DNA in the pineal gland. Research suggests it acts as an epigenetic switch, normalizing the synthesis of endogenous melatonin and serotonin rather than simply replacing them.

At Guardian Labs, we provide Pinealon in its purest lyophilized form. Every batch is HPLC-verified to ensure >99% purity, offering researchers a precise tool for investigating circadian biology, neuroplasticity, and epigenetic modification.

What is Pinealon?

Pinealon consists of three amino acids: Glutamic Acid, Aspartic Acid, and Arginine. This specific sequence allows it to penetrate the cell nucleus and bind to specific chromosomal regions.

Unlike traditional hormone replacement (such as taking synthetic melatonin), Pinealon is studied for its ability to “bioregulate” the pineal gland. This means it may help restore the gland’s functional capacity to produce hormones naturally, making it a primary subject of interest in aging and circadian rhythm research.

Mechanism of Action: Epigenetic Regulation

The biological impact of Pinealon is driven by its interaction with the genome:

• Gene Expression: Pinealon binds to DNA to regulate the expression of genes responsible for protein synthesis in the pineal gland. This “peptide-DNA” interaction is the foundation of the bioregulator theory.

• Circadian Homeostasis: By normalizing pineal function, Pinealon is researched for its ability to reset the circadian clock, improving the sleep-wake cycle and hormonal pulsatility.

• Neuroprotection: Beyond the pineal gland, studies indicate Pinealon has potent antioxidant effects in neural tissue. It effectively reduces the accumulation of reactive oxygen species (ROS), protecting neurons from oxidative stress and hypoxia.

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Potential Research Applications

Pinealon is currently being investigated for its potential to combat age-related decline in brain function. Key areas of study include:

• Circadian Rhythm Disorders: Investigating the restoration of natural sleep cycles in models of jet lag, shift work, or age-related insomnia.

• Cognitive Function: Researching the peptide’s ability to improve memory and learning capacity (nootropic effects) by reducing excitotoxicity in the brain.

• Anti-Aging: Studies examining how resetting the neuro-endocrine system can influence markers of cellular aging and telomere length.

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Scientific References

To validate the specific mechanism of this bioregulator, we reference the following pivotal studies.

1. Neuroprotective Effects in Hypoxia

Summary: This study investigated the effects of Pinealon on the brain cortex during hypoxia (oxygen deprivation). The results showed that Pinealon prevented the accumulation of cytotoxic oxidative byproducts and preserved the number of viable neurons, demonstrating significant neuroprotective activity.

• View the study on PubMed

2. Regulation of Circadian Rhythms

Summary: Research conducted on the “peptide regulation of aging” highlights Pinealon’s role in normalizing melatonin secretion. The data suggests that by interacting with specific genes, short peptides like Pinealon can restore the rhythmic function of the pineal gland that typically degrades with age.

• View the study on PubMed

3. Correction of Psychophysiological State

Summary: In clinical observations involving subjects with high occupational stress, Pinealon administration was associated with a reduction in fatigue and an improvement in psychomotor activity. This suggests the peptide plays a role in regulating the central nervous system’s response to stress.

• View the study on PubMed

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Product Specifications

• Sequence: Glu-Asp-Arg (E-D-R)

• Format: Lyophilized Powder (Freeze-dried)

• Class: Short Peptide / Bioregulator

• Purity: >99% (HPLC Verified)

• Storage: Store at -20°C. Reconstitute with Bacteriostatic Water.

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  Disclaimer: All products listed on this site are for laboratory research and development purposes only. They are not intended for human consumption, diagnostic, or therapeutic use. Customers must be at least 18 years old to purchase.