AOD-9604 (5mg)

Description

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What is AOD-9604 Peptide?

AOD-9604 (Advanced Obesity Drug 9604) is a synthetic peptide fragment comprising the C-terminal amino acids 177-191 of Human Growth Hormone (hGH). To improve stability for research applications, a tyrosine residue is added to the N-terminus.

Unlike full-length hGH, AOD-9604 peptide is highly specific: it is designed to isolate the fat-burning (lipolytic) characteristics of growth hormone without triggering its growth-promoting (anabolic) or insulin-modulating effects.

Mechanism of Action: The “Fat Burning” Fragment

Research indicates that AOD-9604 mimics the body’s natural regulation of fat metabolism. It operates through two primary pathways:

1. Stimulating Lipolysis: It triggers the breakdown of stored fat (triglycerides) in adipose tissue.

2. Inhibiting Lipogenesis: It prevents the deposition of new fat from dietary intake.

3. Beta-3 Adrenergic Receptors: Studies in animal models suggest AOD-9604 upregulates these receptors, which are key drivers of metabolic rate and fat oxidation.

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Research Applications (PubMed Citations)

AOD-9604 is frequently investigated in metabolic research for its favorable safety profile compared to traditional hGH.

1. Targeted Fat Loss & Metabolic Rate In landmark studies using obese Zucker rats, AOD-9604 was shown to reduce body weight gain by over 50% compared to controls. Crucially, this effect was noted specifically in adipose tissue, sparing lean muscle mass.

• Study: Metabolic studies of a synthetic lipolytic domain (AOD9604) of human growth hormone.

• Key Finding: Daily administration significantly reduced body weight gain and increased lipolytic activity without inducing hyperglycemia.

• Read the full study on PubMed

2. Cartilage Repair & Joint Health Emerging research is exploring AOD-9604 for its regenerative properties. In animal models of osteoarthritis, intra-articular injections of AOD-9604 combined with Hyaluronic Acid (HA) showed superior cartilage regeneration compared to HA alone.

• Study: Intra-articular injection of AOD9604 ameliorates collagenase-induced osteoarthritis in rabbits.

• Key Finding: The combination enhanced cartilage regeneration and reduced lameness in rabbit models, suggesting potential beyond just metabolic support.

• Read the full study on PubMed

3. Beta-3 Adrenergic Pathway Activation Research indicates that AOD-9604 may enhance lipolytic sensitivity by upregulating Beta-3 adrenergic receptors in fat cells, a mechanism distinct from direct GH receptor activation.

• Study: The effects of human GH and its lipolytic fragment (AOD9604) on lipid metabolism…

• Key Finding: The peptide increased expression of beta(3)-AR RNA in obese mice to levels comparable to lean mice, restoring metabolic efficiency.

• Read the full study on PubMed

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Protocol & Handling

• Format: Sterile Lyophilized Powder (5mg).

• Reconstitution: Reconstitute with Bacteriostatic Water.

• Storage: Store at -20°C. Avoid repeated freeze-thaw cycles once reconstituted.

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  RUO Disclaimer

  For laboratory research only. Not for human use. Not medical advice.