Sermorelin (10 mg)

Description

What is Sermorelin?

Sermorelin is a synthetic peptide comprising the first 29 amino acids of endogenous Growth Hormone-Releasing Hormone (GHRH). This specific sequence (GHRH 1-29) contains the fully functional biological core required to bind to the GHRH receptor in the anterior pituitary gland.

Distinct from recombinant Human Growth Hormone (rhGH), Sermorelin does not replace the body’s hormone production. Instead, it acts as a secretagogue, stimulating the pituitary to secrete its own natural growth hormone in a pulsatile manner. This mechanism is critical in research as it maintains the hypothalamic-pituitary-somatotropic axis (HPSA) and prevents the “shutdown” of natural production often seen with direct hormone administration.

Mechanism of Action: The Pituitary Signal

Research indicates that Sermorelin mimics the native signaling of GHRH. Upon binding to receptors on somatotroph cells, it triggers the cAMP signaling pathway to:

1. Stimulate GH Release: Inducing the secretion of growth hormone into the bloodstream.

2. Promote Somatotroph Health: Unlike exogenous GH which can cause pituitary atrophy, GHRH analogs are researched for their ability to maintain the glandular tissue.

3. Preserve Feedback Loops: The release of GH induced by Sermorelin is subject to the body’s natural negative feedback (via Somatostatin), making it a safer model for long-term study.

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Research Applications (PubMed Citations)

Sermorelin is widely utilized in protocols focusing on aging, sleep architecture, and metabolic recovery.

1. Sleep Architecture & Slow-Wave Sleep GHRH is a known sleep-promoting substance. Research suggests that GHRH analogs like Sermorelin may enhance non-REM slow-wave sleep (SWS), the deep sleep stage where the majority of physiological repair occurs.

• Study: Ghrelin promotes slow-wave sleep in humans. (Contextual reference on GHS/GHRH pathways).

• Key Finding: GHRH and its analogs are intimately linked to the regulation of nocturnal hormone secretion and deep sleep cycles.

• Read the full study on PubMed

2. Body Composition & Lean Mass Preservation In studies involving aging populations or those with GHD, GHRH analogs have been shown to improve body composition by increasing lean muscle mass and reducing visceral fat without the side effects of hyperglycemia often associated with rhGH.

• Study: Effects of growth hormone-releasing hormone (GHRH) administration on the immune system of aging men and women.

• Key Finding: Administration of GHRH analogs resulted in significant increases in IGF-1 levels and favorable shifts in cellular immune function.

• Read the full study on PubMed

3. Diagnostic Utility & Safety Sermorelin is historically FDA-approved (as Geref) for diagnosing pituitary function. Its safety profile is well-documented in research, showing a lack of adverse effects on glucose parameters compared to other secretagogues.

• Study: Sermorelin: a review of its use in the diagnosis and treatment of children with idiopathic growth hormone deficiency.

• Key Finding: Confirms Sermorelin’s specific ability to stimulate the anterior pituitary with a high safety margin.

• Read the full study on PubMed

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  Protocol & Handling

• Format: Sterile Lyophilized Powder (10mg).

• Reconstitution: Reconstitute with Bacteriostatic Water.

• Storage: Store at -20°C. Avoid repeated freeze-thaw cycles.

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  RUO Disclaimer

  For laboratory research only. Not for human use. Not medical advice.