Description

Tesamorelin (Trans-3-Hexenoyl GHRH)

Tesamorelin is a synthetic peptide analogue of Growth Hormone Releasing Hormone (GHRH). Structurally, it consists of the first 44 amino acids of human GHRH, modified with a trans-3-hexenoyl group at the N-terminus. This structural modification significantly improves its stability and resistance to enzymatic degradation compared to native GHRH.

At Guardian Labs, we provide research-grade Tesamorelin that is rigorously tested to ensure >99% purity. Our commitment to quality ensures that your laboratory data regarding visceral adiposity and pituitary function remains accurate and reproducible.

What is Tesamorelin?

Tesamorelin is widely recognized in the scientific community for its unique ability to stimulate the release of growth hormone (GH) with a high degree of specificity. Unlike other GHRH analogues, Tesamorelin has been the subject of extensive clinical research specifically regarding the reduction of visceral adipose tissue (VAT).

The addition of the trans-3-hexenoyl group allows the peptide to remain active in the system longer than natural GHRH, providing a sustained stimulation of the pituitary gland. This results in the pulsatile release of growth hormone, which subsequently triggers the production of Insulin-Like Growth Factor 1 (IGF-1) from the liver.

Mechanism of Action

Tesamorelin acts as a potent agonist of the GHRH receptor. Upon binding to receptors in the anterior pituitary, it stimulates the synthesis and secretion of growth hormone.

Specificity for Visceral Fat

Research distinguishes Tesamorelin from other peptides like CJC-1295 due to its documented efficacy in targeting visceral fat (deep abdominal fat). Studies suggest that the specific pulsatile pattern induced by Tesamorelin promotes lipolysis in visceral fat depots more effectively than subcutaneous fat depots.

Potential Research Applications

While strictly for laboratory and in-vitro use, Tesamorelin is a primary subject of investigation in the following areas:

• Visceral Adiposity: Investigating the reduction of deep abdominal fat in metabolic syndrome models.

• Cognitive Function: Research into the effects of GHRH analogues on executive function and mild cognitive impairment (MCI).

• Muscle Quality: Studies analyzing the relationship between reduced myosteatosis (muscle fat) and improved muscle density.

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Scientific References

To validate the research potential of this peptide, we reference the following peer-reviewed studies. These trials highlight the efficacy of Tesamorelin in metabolic and cognitive applications.

1. Reduction of Visceral Adipose Tissue (VAT)

Summary: In a landmark randomized clinical trial involving subjects with abdominal fat accumulation, Tesamorelin administration resulted in a significant reduction in visceral adipose tissue (VAT) area. The study noted that this reduction was achieved without altering subcutaneous fat or body mass index (BMI) significantly, highlighting the peptide’s specificity.

• View the study on PubMed

2. Cognitive Function & MCI

Summary: This study examined the effects of GHRH administration on cognitive function in healthy older adults and those with Mild Cognitive Impairment (MCI). The results indicated a favorable effect on executive function and verbal memory, suggesting a potential neuroprotective role for GHRH analogues like Tesamorelin.

• View the study on PubMed

3. Improvement in Muscle Density

Summary: A secondary analysis of clinical trials found that Tesamorelin treatment was associated with significant increases in paraspinal muscle density. This suggests that the peptide may help reduce fat infiltration within muscle tissue (myosteatosis), thereby improving overall muscle quality.

• View the study on PubMed

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  Product Specifications

• Sequence: trans-3-hexenoyl-[Tyr1]hGRF(1-44)NH2

• Format: Lyophilized Powder (Freeze-dried)

• Vial Size: 2mg / 5mg

• Purity: >99% (HPLC Verified)

• Storage: Store at -20°C. Reconstitute with Bacteriostatic Water.

Disclaimer: All products listed on this site are for laboratory research and development purposes only. They are not intended for human consumption, diagnostic, or therapeutic use. Customers must be at least 18 years old to purchase.