Thymosin Beta 4 (TB500)

Description

Thymosin Beta 4 (TB-500) is a synthetic fraction of the naturally occurring protein thymosin beta-4. This research peptide is widely studied for its potential role in cellular migration, actin sequestration, and tissue regeneration. Each vial contains lyophilized powder, strictly for laboratory use.

What is Thymosin Beta 4 (TB-500)?

While often referred to interchangeably, TB-500 specifically refers to the synthetic peptide sequence (Ac-SDKP) that mimics the active domain of the natural Thymosin Beta 4 protein.

• Mechanism: It functions primarily by regulating actin, a cell-building protein essential for structure and movement.

• Actin Sequestration: Research shows it can bind to actin monomers, potentially preventing them from polymerizing until needed for cell repair.

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Research Applications

Thymosin Beta 4 (TB-500) is a primary subject in regenerative medicine studies conducted by Guardian Labs partners and researchers worldwide.

1. Wound Healing: Studies in animal models suggest it may accelerate the closure of dermal wounds by promoting keratinocyte migration.

2. Inflammation Control: Research indicates it may reduce the presence of pro-inflammatory cytokines in damaged tissue.

3. Cardiac Research: It is heavily investigated for its potential role in cardiovascular recovery and angiogenesis (formation of new blood vessels) following ischemic events.

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Published Research & Clinical Data

At Guardian Labs, we prioritize transparency and education. Below are key peer-reviewed studies regarding Thymosin Beta 4 (TB-500) and its biological mechanisms.

• Study 1: Tissue Repair & Dermal Healing

  • Title: Thymosin β4 Promotes Dermal Healing

  • Summary: This study demonstrates the peptide’s ability to promote cell migration and reduce inflammation in injured tissues, specifically in dermal wound models.

  • Read the full study on PubMed

• Study 2: Cardiac Recovery & Angiogenesis

  • Title: Thymosin-β4 prevents cardiac rupture and improves cardiac function in mice with myocardial infarction

  • Summary: Research highlights the potential of TB-500 in repairing damaged heart tissue following ischemic events by stimulating new blood vessel growth and reducing cell death.

  • Read the full study on PubMed

• Study 3: Actin Sequestration Mechanism

  • Title: Structural basis of thymosin-β4/profilin exchange leading to actin filament polymerization

  • Summary: A detailed look at how this peptide binds to actin monomers, which is the foundational mechanism for its regenerative properties.

  • Read the full study on PubMed

Storage and Reconstitution

• Format: Sterile Lyophilized Powder.

• Storage: Store at -20°C (freezer) to maintain stability.

• Reconstitution: Reconstitute with bacteriostatic water. Once dissolved, keep refrigerated at 4°C and use within 8 days (as TB-500 is known to degrade faster in solution than other peptides).

Why Buy from Guardian Labs?

We offer Thymosin Beta 4 (TB-500) with verified purity reports (HPLC/MS). We guarantee the correct molecular weight and sequence for your research needs. For questions about shipping or bulk orders, please Contact Us.

For Research Use Only: This product (Thymosin Beta 4 or TB-500) is intended strictly for laboratory and research purposes. It is not intended for human consumption, injection, or use as a drug, food, or cosmetic.

Handling and Usage:

• This product should only be handled by qualified professionals or researchers.
• The material is supplied in a lyophilized (freeze-dried) state and requires reconstitution with bacteriostatic water or a sterile solvent.
• By purchasing this product, the buyer acknowledges that they understand the potential hazards associated with the handling of research chemicals.

Legal Compliance: Guardian Labs does not endorse the use of this product for performance enhancement or medical treatment. All buyers must be at least 18 years of age.